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The incidence of these events is consistent with that observed in populations of multiple sclerosis patients followed for a prolonged period of time.

Small increases in pulse rate and transient hypotension have been observed following initial dose introduction.Įpisodes of feeling faint and occasional faints have been observed with use of SATIVEX. These generally resolve rapidly if further doses are withheld and can usually be avoided or minimised thereafter by careful reduction of dosing or by increasing the interval between doses. Patients who complain of discomfort at the application site should be advised to vary the site of application within the mouth and should not continue spraying onto sore or inflamed mucus membrane. 07 patients have received more than six months treatment with SATIVEX. THC is a partial agonist at CB1 receptors and can behave as either an agonist or antagonist at CB2.Īdverse Events. CB1 is predominantly distributed in the central nervous system, while CB2 is localised predominantly in immune cells.

Its precise mechanism of action is unknown. They usually remit on reduction of doses, increasing the interval between doses or interruption of SATIVEX. Fainting episodes have been observed with use of SATIVEX. Patients should be advised that it might take a week or more to find the optimal dosing level. Geriatrics: There are limited data available on the use of SATIVEX.

THC is a psychotropic agent which may produce physical and psychological dependence and has the potential to be abused. Sleep disturbance was also significantly reduced. 5Dear Health Care Professional,GW Pharma Ltd. Contact the company for a copy of any references, attachments or enclosures.Īpril 2. This is a duplicated text of a letter from GW Pharma Ltd. Introductory Para - Each monograph begins with an introductory paragraph.Ī SHORT GRAPHICAL HISTORY INDIA CANNABIS IN INDIA. 1753 Linnaeus classifies Cannabis sativa. 13th Century The oldest monograph on hashish. Any questions regarding product information should be discussed with your health care professional. Health Canada posts safety alerts, public health advisories, press releases and other notices from industry as a service to health professionals, consumers and other interested parties. Point (PPT) files, can be obtained in the alternate format help section. Help on accessing alternative formats, such as Portable Document Format (PDF), Microsoft Word and Power.